From Proteopedia
proteopedia link proteopedia link Solution structure of the PKD domain from KIAA 1837 protein
Structural highlights
2yrl is a 1 chain structure with sequence from Homo sapiens . Full experimental information is available from OCA . For a guided tour on the structure components use FirstGlance . Gene: KIAA1837 (Homo sapiens ) Resources: FirstGlance , OCA , RCSB , PDBsum , TOPSAN
Disease
[K319L_HUMAN ] Systemic lupus erythematosus;Limited cutaneous systemic sclerosis.
Function
[K319L_HUMAN ] Possible role in axon guidance through interaction with RTN4R.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB . You may read the explanation of the method and the full data available from ConSurf .
References
↑ Poon MW, Tsang WH, Chan SO, Li HM, Ng HK, Waye MM. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. Cell Mol Neurobiol. 2011 Jan;31(1):27-35. doi: 10.1007/s10571-010-9549-1. Epub, 2010 Aug 10. PMID:20697954 doi:http://dx.doi.org/10.1007/s10571-010-9549-1
