Structural highlights
Publication Abstract from PubMed
The crystal structure of a decameric HNA/RNA (HNA = 2',3'-dideoxy-1',5'-anhydro-d-arabinohexitol nucleic acid) hybrid with the RNA sequence 5'-GGCAUUACGG-3' is the first crystal structure of a hybrid duplex between a naturally occurring nucleic acid and a strand, which is fully modified to contain a six-membered ring instead of ribose. The presence of four duplex helices in the asymmetric unit allows for a detailed discussion of hydration, which revealed a tighter spinelike backbone hydration for the HNA- than for the RNA-strands. The reinforced backbone hydration is suggested to contribute significantly to the exceptional stability of HNA-containing duplexes and might be one of the causes for the evolutionary preference for ribose-derived nucleic acids.
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.,Maier T, Przylas I, Strater N, Herdewijn P, Saenger W J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Maier T, Przylas I, Strater N, Herdewijn P, Saenger W. Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid. J Am Chem Soc. 2005 Mar 9;127(9):2937-43. PMID:15740130 doi:10.1021/ja045843v
