2jd1

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Image:2jd1.gif

2jd1, resolution 2.00Å

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X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS, IN COMPLEX WITH MANGANESE AND NADPH

Overview

Isopentenyl diphosphate is the precursor of various isoprenoids that are, essential to all living organisms. It is produced by the mevalonate, pathway in humans but by an alternate route in plants, protozoa, and many, bacteria. 1-deoxy-D-xylulose-5-phosphate reductoisomerase catalyzes the, second step of this non-mevalonate pathway, which involves an, NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose, 5-phosphate to form 2-C-methyl-D-erythritol 4-phosphate. The use of, different pathways, combined with the reported essentiality of the enzyme, makes the reductoisomerase a highly promising target for drug design. Here, we present several high resolution structures of the Mycobacterium, tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase, representing, both wild type ... [(full description)]

About this Structure

2JD1 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with MN, SO4 and NDP as [ligands]. Active as [1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [1.1.1.267]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase provide new insights into catalysis., Henriksson LM, Unge T, Carlsson J, Aqvist J, Mowbray SL, Jones TA, J Biol Chem. 2007 Jul 6;282(27):19905-16. Epub 2007 May 9. PMID:17491006

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