UBC13 MMS2

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==UBC13-MMS2 E2 Complex==

Contents 1 Summary 2 Function 3 Inhibitors 4 Coordinating Enzymes 5 Pathway for DNA Repair 6 Structural Highlights/Important Residues 7 Mechanism 8 References

Summary

Ubc13 is an E2 ubiquitin conjugating enzyme that lacks function without forming a heterodimer with Mms2. Ubc13 is involved in pathways that repair double stranded damage in DNA molecules. When bound to Mms2, Ubc13 will polyubiquinate PCNA, proliferating cell nuclear antigen. Many proteins that Ubc13 interacts with are RING finger proteins such as Traf6.

Function

UBC13 functions as a heterodimer with MMS2, a structurally similar protein to UBC13, but lacking the catalytic Cysteine residue in the active site. The UBC13 E2 complex with MMS2 functions primarily to enhance DNA repair from double stranded breaks.

Inhibitors

Coordinating Enzymes

Pathway for DNA Repair

Structural Highlights/Important Residues

Mechanism

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References