Introduction
The Enoyl-ACP Reductase InhA, from Mycobacterium tuberculosis, catalyzes the NADH-dependent reduction of long-chain trans-2-enoyl-ACP fatty acids in the type II fatty acid biosynthesis pathway of M. tuberculosis. InhA is a member of the short chain dehydrogenase/reductase (SDR) family of enzymes. InhA is the only enoyl-ACP reductase found in tuberculosis, making the enzyme a potential drug target.
FAS-II System
Mechanism of Action
Structure
Fatty Acyl Binding Crevice
Catalytic Triad
Hydrogen Bonding Interactions
Clinical Applications
Isoniazid
Other Inhibitors
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