2rf3

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Image:2rf3.jpg

2rf3, resolution 1.75Å

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Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles

Overview

The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

About this Structure

2RF3 is a Single protein structure of sequence from [1] with and as ligands. Known structural/functional Sites: and . Full crystallographic information is available from OCA.

Reference

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles., Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M, Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536

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