Glutaryl-CoA dehydrogenase

Function

Glutaryl-CoA dehydrogenase (GCD) converts glutaryl-CoA to crotonyl-CoA. GCD is part of the metabolism of lysine and tryptophan.

Disease

Defective GCD causes the often fatal glutaric acidemia.

Relevance

Structural highlights

3D structures of glutaryl-CoA dehydrogenase

Updated on 08-April-2015

3d6b, 3eom, 3ii9 – BpGCD – Burkholderia pseudomallei

3eon – BpGCD + difluorophenyl methanol
3gqt – BpGCD + quinoxaline derivative
3gnc – BpGCD + piperazine derivative
3mpi – DmGCD + FAD + glutaryl-CoA – Desulfococcus multivorans
3mpj – DmGCD + FAD + peptide

• • 1siq, 1sir – hGCD + FAD - human
    
  • 2r0m – hGCD (mutant) + FAD + dienolate intermediate
    
  • 2r0n – hGCD (mutant) + FAD + thiaglutarate-CoA
    
  • 3sf6, 3swo – GCD + FDA – Mycobacterium smegmatis
    

References