Hirudin

From Proteopedia

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Template:STRUCTURE 1hic

Hirudin (Hir) is a powerful anticoagulant which is found in the leech salivary glands. It is an inhibitor of thrombin (Thr) which converts fibrinogen to fibrin upon blood clotting. Thrombin is produced upon enzymatic cleavage of prothrombin (ProThr). Hirugen (Hirg) is a dodecapeptide of the C-terminal of Hir (sequence NDGDFEEIPEEYL). The image at the right correspond to one representative Hirudin, i.e. the NMR Structure of Hirudin (1hic). For additional details see Sean Swale/Human Thrombin Inhibitor.

3D Structures of Hirudin

Updated on 21-April-2015 {{#tree:id=OrganizedByTopic|openlevels=0|

• Hirudin

• • 1hic, 2hir, 4hir, 5hir, 6hir – Hir – NMR
    
  • 2joo - Hir – NMR
    

• Hirudin + Thrombin light and heavy chains

• • 1hrt, 3htc, 4htc - Hir +hThr L&H chains
    
  • 3da9, 3utu - Hir peptide+hThr L&H chains
    
  • 3qtv, 3qwc, 3qx5 - Hir peptide + hThr L&H chains + pyridine derivative
    
  • 3rlw, 3rly, 3rm0, 3rm2, 3rml, 3rmm, 3rmn, 3rmo - Hir peptide + hThr L&H chains + inhibitor
    
  • 3qto - Hir +hThr L&H chains + pyridine derivative

• Hirugen + Thrombin light and heavy chains

• • 2zhe, 2zhf, 2zhw, 2zg0, 2zfq, 2zfr, 1c5l, 1hxf, 1hah, 1hai, 1abi, 1abj, 1hgt, 2uuf, 1aix, 1ay6, 1awf, [[2hgt] - Hirg+ hThr L&H chains
    

• Hirugen + prothrombin

• • 2cn0, 3c1k – Hirg+ hProThr
    
  • 1t4u, 1t4v, 1o5g, 1g30, 1g32, 1twx, 3tu7, 4ax9, 1sb1 - Hirg+hProThr+inhibitor
    

• Hirugen + Prethrombin

• • 1hag – Hirg+hPreThr
    

• Hirugen + thrombin heavy chain

• • 1nm6 – Hirg+ hThr H chain
    
  • 1nt1 - Hirg+ hThr H chain+inhibitor
    

• Hirugen + thrombin light and heavy chains+inhibitor

• • 1fph, 7kme, 1d6w - Hirg +hThr L&H chains+polypeptide
    
  • 1hxe - Hirg +hThr L&H chains+Rb
    
  • 1ypk, 1riw, 1mu6, 1mu8, 1mue, 1no9, 1oyt, 1o2g, 1ny2, 1gj4, 1gj5, 1kts, 1ktt, 1ghv, 1ghw, 1ghx, 1ghy, 1h8i, 1h8d, 1c5n, 1c5o, 1c1u, 1c1v, 1c1w, 1qj1, 1qj6, 1qj7, 1qbv, 1bcu, 1a2c, 1a61, 1a46, 1a5g, 1b5g, 1ad8, 1ai8, 1tom, 1bmm, 1bmn, 1lhc, 1lhd, 1lhe, 1lhf, 1lhg, 1uma, 1aht, 1fpc, 3hat, 1tmu, 1dwb, 1dwc, 1dwd, 1dwe, 1tmb, 3f68, 3eq0, 3dt0, 3dux, 3dhk, 2znk, 2zo3, 3d49, 2zhq, 2zi2, 2ziq, 2zff, 2zfp, 2zgb, 2zgx, 2zf0, 2zc9, 2zda, 2zdv, 3egk, 2pw8, 3c27, 2r2m, 2cf8, 2cf9, 2bdy, 2v3h, 2v3o, 1w7g, 1ype, 1ypg, 1ypj, 3biu, 3biv, 1doj, 1ypl, 1ypm, 1vzq, 1way, 1wbg, 1k21, 1k22, 1afe, 1ae8 ,1a3b, 1a3e, 1vr1, 2bvr, 2bvs, 2bvx, 2bxt, 2bxu, 2gde, 2pks, 3ldx, 3p17, 1d9i, 1xm1, 4n3l, 4nze, 1ba8, 1bb0, 1c4u, 1ca8, 1d3d, 1d3p, 1d3q, 1d3t, 1d4p, 1hdt, 1ihs, 1iht, 1o0d, 1qhr, 1tbz, 4ayv, 4ayy, 4az2 – Hirg+ hThr L&H chains+inhibitor
    
  • 2feq, 2fes – Hirg analog + hThr L&H chains+inhibitor
    
  • 3sha, 3shc, 3si3, 3si4, 3sv2, 3t5f, 3u98, 3u9a, 3uwj, 4ban, 4bao, 4e7r, 4loy – Hirg variant 2 + hThr L&H chains+inhibitor
    
  • 4bah, 4bak, 4bam, 4baq, [[4lxb, 4mlf]] – Hirg variant 1 + hThr L&H chains+inhibitor
    

• Hirugen+Thrombin light and heavy chains+ protein

• • 1vit - Hirg+hThr L&H chains+ε-hThr
    
  • 1nrs - Hirg+hThr L&H chains + receptor based peptide
    

• Hirugen+ α-Thrombin +inhibitor

• • 1zrb, 1z71, 1sl3, 1ta2, 1ta6, 1zgi, 1zgv, 2uuk, 2uuj, 2jh0, 2jh5, 2jh6, 2c8w, 2c8x, 2c8y, 2c8z, 2c90, 2c93, 8kme – Hirg+α-hThr+inhibitor
    

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