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You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
Ricin is defined as a type 2 ribosome inactivating protein (RIP). Type 1 RIPs are made up of a single protein chain that demonstrate catalytic activity. Type 2 RIPs are made up of two protein chains which together will form a heterodimeric complex. Type 2 RIPs consist of an A chain that functions similarly to the type 1 RIP, bonded together by a disulfide bond and joining together a B chain. Although the B chain doesn’t demonstrate any catalytic activity, it does act in the transport of the AB chain from the cell surface. The AB chain is transported by vesicle carriers to the endoplasmic reticulum. Once the ribosome inactivating proteins have entered the body, both type 1 and type 2 RIPs are fully functional and destructive to the ribosomes. Although both RIP types are functional at this state, only type 2 will show cytotoxicity. This is because of the lectin properties that makeup the B chain. In order for the ribosome inactivating properties to be displayed, the ricin disulfide bond must be cleaved.
Disease
Relevance
Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
