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Function
MMP9 is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 may also play an important part in local proteolysis of the extracellular matrix and in leukocyte migration, as well as in bone osteoclastic resorption.
MMP-9 is absent from most normal adult tissues, including the intestinal epithelial cells. We and several others have shown that MMP-9 is highly expressed during intestinal inflammation in different animal models and human IBD. In addition to its role in inflammation, recent studies from our laboratory have shown that MMP-9 plays a role in epithelial cell differentiation.
Disease
Matrix metalloproteinase (MMP)-9, one of the most widely investigated MMPs, regulates pathological remodeling processes that involve inflammation and fibrosis in cardiovascular disease. MMP-9 directly degrades extracellular matrix (ECM) proteins and activates cytokines and chemokines to regulate tissue remodeling. MMP-9 deletion or inhibition has proven overall beneficial in multiple animal models of cardiovascular disease.
Relevance
Structural highlights
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