Ferredoxin NADP+ Reductase

Ferredoxin NADP⁺ reductase</ref is an enzyme that catalyzes the reduction of NADP⁺ to NADPH. This enzyme belongs to a family of enzymes called oxidoreductases[1] that contain iron-sulfur proteins as electron donors and NAD⁺ or NADP⁺ as electron acceptors. FAD, [flavin adenine dinucleotide][2], is also a cofactor of FNR. The ferredoxin NADP⁺ reductase participates in a general reaction that proceeds as follows:

2 reduced ferredoxin + NADP⁺ ---> H⁺ + 2 oxidized ferredoxin + NADPH^[1]

Structural highlights

In its active form, the protein is a and contains a [4Fe-4S]⁺² cluster. When inactive, the protein is monomeric and containts a [3Fe-4S]⁺² cluster. FNR in its form can be seen here, with bound NADP and FAD^[2]