1a9l

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Image:1a9l.gif

1a9l

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SOLUTION STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, NMR, 12 STRUCTURES

Overview

The structure of the bulge-helix-bulge motif that constitutes the, intron/exon splice site in H. volcanii pre-tRNATrp has been determined by, NMR spectroscopy. The conformations of the two 3 nt bulges, where the, pre-tRNA is cleaved, are stabilized by stacking interactions between bulge, nucleotides and bases in the adjacent Watson-Crick helices and by a, network of backbone hydrogen bonds. Both bulges are presented on the same, minor groove face of the central 4 bp helix, and the overall structure has, approximate two-fold symmetry, which makes it well-suited for attack by, archaeal splicing endonucleases, which are symmetric dimers.

About this Structure

1A9L is a [Protein complex] structure of sequences from [[1]]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].

Reference

Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971

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