Structural highlights
Function
[RAB14_HUMAN] Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.[1] [RFIP1_HUMAN] A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and in phagocytosis.[2] [3] [4] [5]
References
- ↑ Linford A, Yoshimura S, Nunes Bastos R, Langemeyer L, Gerondopoulos A, Rigden DJ, Barr FA. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. Dev Cell. 2012 May 15;22(5):952-66. doi: 10.1016/j.devcel.2012.04.010. PMID:22595670 doi:http://dx.doi.org/10.1016/j.devcel.2012.04.010
- ↑ Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. J Biol Chem. 2002 Apr 5;277(14):12190-9. Epub 2002 Jan 10. PMID:11786538 doi:http://dx.doi.org/10.1074/jbc.M108665200
- ↑ Peden AA, Schonteich E, Chun J, Junutula JR, Scheller RH, Prekeris R. The RCP-Rab11 complex regulates endocytic protein sorting. Mol Biol Cell. 2004 Aug;15(8):3530-41. Epub 2004 Jun 4. PMID:15181150 doi:http://dx.doi.org/10.1091/mbc.E03-12-0918
- ↑ Damiani MT, Pavarotti M, Leiva N, Lindsay AJ, McCaffrey MW, Colombo MI. Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. Traffic. 2004 Oct;5(10):785-97. PMID:15355514 doi:http://dx.doi.org/10.1111/j.1600-0854.2004.00220.x
- ↑ Jin M, Goldenring JR. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Biochim Biophys Acta. 2006 Jun;1759(6):281-95. Epub 2006 Jun 27. PMID:16920206 doi:http://dx.doi.org/S0167-4781(06)00093-5
