2n2q

Structural highlights

Function

[DEF1_HEUSA] Possesses antifungal activity insensitive to inorganic cations. Causes germ tubes and hyphae to swell and form multiple hyphal buds. Binds to the plasma membrane of the fungus. Has no inhibitory effect on insect gut alpha-amylase.^{[1] [2] [3]}

References

1. ↑ De Lucca AJ, Jacks TJ, Broekaert WJ. Fungicidal and binding properties of three plant peptides. Mycopathologia. 1998-1999;144(2):87-91. PMID:16284838 doi:http://dx.doi.org/10.1023/A:1007018423603
2. ↑ Osborn RW, De Samblanx GW, Thevissen K, Goderis I, Torrekens S, Van Leuven F, Attenborough S, Rees SB, Broekaert WF. Isolation and characterisation of plant defensins from seeds of Asteraceae, Fabaceae, Hippocastanaceae and Saxifragaceae. FEBS Lett. 1995 Jul 17;368(2):257-62. PMID:7628617
3. ↑ Thevissen K, Osborn RW, Acland DP, Broekaert WF. Specific, high affinity binding sites for an antifungal plant defensin on Neurospora crassa hyphae and microsomal membranes. J Biol Chem. 1997 Dec 19;272(51):32176-81. PMID:9405418