1eqy

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Image:1eqy.gif


PDB ID 1eqy

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, resolution 2.3Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



COMPLEX BETWEEN RABBIT MUSCLE ALPHA-ACTIN: HUMAN GELSOLIN DOMAIN 1


Contents

Overview

The structure of the segment 1 domain of gelsolin, a protein that fragments actin filaments in cells, is reported in complex with actin. Segment 1 binds monomer using an apolar patch rimmed by hydrogen bonds in a cleft between actin domains. On the actin filament model it binds tangentially, disrupting only those contacts between adjacent subunits in one helical strand. The segment 1 fold is general for all segments of the gelsolin family because the conserved residues form the core of the structure. It also provides a basis for understanding the origin of an amyloidosis caused by a gelsolin variant.

Disease

Known disease associated with this structure: Amyloidosis, Finnish type OMIM:[137350]

About this Structure

1EQY is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Structure of gelsolin segment 1-actin complex and the mechanism of filament severing., McLaughlin PJ, Gooch JT, Mannherz HG, Weeds AG, Nature. 1993 Aug 19;364(6439):685-92. PMID:8395021

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