2bjr

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spinqualitylabelsall models 2bjr, resolution 1.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF THE NEMATODE SPERM CELL MOTILITY PROTEIN MFP2B

Overview

The simplicity and specialization of the cell motility machinery of, Ascaris sperm provides a powerful system in which to probe the basic, molecular mechanism of amoeboid cell motility. Although Ascaris sperm, locomotion closely resembles that seen in many other types of crawling, cell, movement is generated by modulation of a cytoskeleton based on the, major sperm protein (MSP) rather than the actin present in other cell, types. The Ascaris motility machinery can be studied conveniently in a, cell-free in vitro system based on the movement of plasma membrane, vesicles by fibres constructed from bundles of MSP filaments. In addition, to ATP, MSP and a plasma membrane protein, reconstitution of MSP motility, in this cell-free extract requires cytosolic proteins to orchestrate the, ... [(full description)]

About this Structure

2BJR is a [Single protein] structure of sequence from [Ascaris suum] with ZN and SO4 as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility., Grant RP, Buttery SM, Ekman GC, Roberts TM, Stewart M, J Mol Biol. 2005 Apr 1;347(3):583-95. PMID:15755452

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