While DNA contains all the genetic material in a cell, proteins play an important role in regulating the transcription of DNA to RNA, not to mention replication, repair and packaging.. The interactions between DNA and proteins are important in this process. Most sequence specific interactions occur in the major grove, as portions of the bases are exposed in this groove. In contrast, the minor groove contains more of the carbohydrate portions of DNA.
Helix-Turn-Helix Interactions with DNA
Leucine zippers
Zinc fingers