2nmv

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spinqualitylabelsall models PDB ID 2nmv Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
, resolution 2.95Å
Ligands:	, and
Gene:	uvrB (Bacillus subtilis)
Coordinates:	save as pdb, mmCIF, xml

Damage detection by the UvrABC pathway: Crystal structure of UvrB bound to fluorescein-adducted DNA

Overview

UvrB is the damage recognition element of the highly conserved UvrABC pathway that functions in the removal of bulky DNA adducts. Pivotal to this is the formation of a damage detection complex that relies on the ability of UvrB to locate and sequester diverse lesions. Whilst structures of UvrB bound to DNA have recently been reported, none address the issue of lesion recognition. Here, we describe the crystal structure of UvrB bound to a pentanucleotide containing a single fluorescein-adducted thymine that reveals a unique mechanism for damage detection entirely dependent on the exclusion of lesions larger than an undamaged nucleotide.

About this Structure

2NMV is a Protein complex structure of sequences from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Damage detection by the UvrABC pathway: crystal structure of UvrB bound to fluorescein-adducted DNA., Waters TR, Eryilmaz J, Geddes S, Barrett TE, FEBS Lett. 2006 Nov 27;580(27):6423-7. Epub 2006 Nov 3. PMID:17097086

Page seeded by OCA on Thu Mar 20 17:48:19 2008