1uqu
From Proteopedia
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TREHALOSE-6-PHOSPHATE FROM E. COLI BOUND WITH UDP-GLUCOSE.
Overview
Trehalose is an unusual non-reducing disaccharide that plays a variety of, biological roles, from food storage to cellular protection from, environmental stresses such as desiccation, pressure, heat-shock, extreme, cold, and oxygen radicals. It is also an integral component of the, cell-wall glycolipids of mycobacteria. The primary enzymatic route to, trehalose first involves the transfer of glucose from a UDP-glucose donor, to glucose-6-phosphate to form alpha,alpha-1,1 trehalose-6-phosphate. This, reaction, in which the configurations of two glycosidic bonds are set, simultaneously, is catalyzed by the glycosyltransferase, trehalose-6-phosphate synthase (OtsA), which acts with retention of the, anomeric configuration of the UDP-sugar donor. The classification of, activated ... [(full description)]
About this Structure
1UQU is a [Single protein] structure of sequence from [Escherichia coli] with UPG as [ligand]. Active as [Alpha,alpha-trehalose-phosphate synthase (UDP-forming)], with EC number [2.4.1.15]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
The donor subsite of trehalose-6-phosphate synthase: binary complexes with UDP-glucose and UDP-2-deoxy-2-fluoro-glucose at 2 A resolution., Gibson RP, Tarling CA, Roberts S, Withers SG, Davies GJ, J Biol Chem. 2004 Jan 16;279(3):1950-5. Epub 2003 Oct 21. PMID:14570926
Page seeded by OCA on Tue Oct 30 16:08:39 2007
