1m0t

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Image:1m0t.jpg


PDB ID 1m0t

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, resolution 2.30Å
Ligands:
Gene: GSH2 (Saccharomyces cerevisiae)
Activity: Glutathione synthase, with EC number 6.3.2.3
Coordinates: save as pdb, mmCIF, xml



Yeast Glutathione Synthase


Overview

Glutathione synthase catalyzes the final ATP-dependent step in glutathione biosynthesis, the formation of glutathione from gamma-glutamylcysteine and glycine. We have determined structures of yeast glutathione synthase in two forms: unbound (2.3 A resolution) and bound to its substrate gamma-glutamylcysteine, the ATP analog AMP-PNP, and two magnesium ions (1.8 A resolution). These structures reveal that upon substrate binding, large domain motions convert the enzyme from an open unliganded form to a closed conformation in which protein domains completely surround the substrate in the active site.

About this Structure

1M0T is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Large conformational changes in the catalytic cycle of glutathione synthase., Gogos A, Shapiro L, Structure. 2002 Dec;10(12):1669-76. PMID:12467574

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