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1s7o

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Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes

Structural highlights

1s7o is a 3 chain structure with sequence from Streptococcus pyogenes serotype m3. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	SPY1201, SPYM3_0842, SPS1042, SPYM18_1152 (Streptococcus pyogenes serotype M3)
Resources:	FirstGlance, OCA, RCSB, PDBsum, TOPSAN

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the putative DNA-binding protein SP_1288 (gi/15675166, also listed as gi/28895954) from Streptococcus pyogenes has been determined by X-ray crystallography to a resolution of 2.3 A using anomalous diffraction data at the Se peak wavelength. SP_1288 belongs to a family of proteins whose cellular function is associated with the signal recognition particle; no structural information has been available until now about the members of the family. Crystallographic analysis revealed that the overall fold of SP_1288 consists exclusively of alpha-helices and that 75% of the structure has good similarity to domain 4 of the sigma subunit of RNA polymerase. This suggests its possible involvement in the biochemical function of transcription initiation, which includes interaction with DNA.

Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes.,Oganesyan V, Pufan R, DeGiovanni A, Yokota H, Kim R, Kim SH Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1266-71. Epub 2004, Jun 22. PMID:15213388^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Oganesyan V, Pufan R, DeGiovanni A, Yokota H, Kim R, Kim SH. Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes. Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1266-71. Epub 2004, Jun 22. PMID:15213388 doi:10.1107/S0907444904009394

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

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1s7o

From Proteopedia

Crystal structure of putative DNA binding protein SP_1288 from Streptococcus pygenes

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

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