Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.
Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution.,Cramer JF, Nordberg PA, Hajdu J, Lejon S FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Cramer JF, Nordberg PA, Hajdu J, Lejon S. Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution. FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979 doi:10.1016/j.febslet.2007.06.003
