Best example is PDB entry 4ivt and is shown in the viewer.
Molecule Beta-secretase 1, also known as Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Aspartyl protease 2, Asp 2, ASP2, Memapsin-2, Beta-secretase 1 and Beta-site APP cleaving enzyme 1.
Function
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot P56817
Catalytic Activity
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.Data source: Uniprot P56817
Disease
Relevance
Structural highlights
Biological process
Is involved in the following biological processes:
proteolysis
In structures
Beta-secretase 1 is found in 323 PDB entries
- Eukaryota (323 PDB entries):
- Homo sapiens (323 PDB entries):
