Cyclin-dependent kinase
From Proteopedia
Template:STRUCTURE 3rgf
Cyclin-dependent kinase (CDK) are serine/threonine kinases which are important to the regulation of the cell cycle. CDKs are small proteins which contain just a kinase domain. In order to function, CDK binds the regulatory protein cyclin. CDKs phosphorylate their substrates at a consensus tetrapeptide. The CDK classes differ by the binding cyclin and their function in human.
• For details on CDK2 see Cell Division Protein Kinase 2.
• CDK3 binds cyclin C and functions during the G1 phase.
• For details on CDK4 see Cyclin Dependent Kinase-4.
- CDK5 binds p53 and functions during transcription.
• CDK6 binds cyclin D and functions during the G1 phase.
• CDK7 may serve as a direct link between transcription regulation and the cell cycle.
• CDK8 binds cyclin C and functions during transcription.
• CDK12 phosphorylates the C-terminal domain of the large subunit of RNA polymerase II. Acts as a regulator of transcription elongation.
• CDK16 plays a role in vescicle-mdiated transport processes and exocytosis.
3D structures of cyclin-dependent kinase
Updated on 20-November-2014
