Function
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a prokaryotic enzyme which is part of the folate synthesis pathway. HPPK catalyzes the attachment of pyrophosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (HMDP) to form
6-hydroxymethyl-7,8-dihydropteridine pyrophosphate.
Disease
Relevance
HPPK is a potential target for antimicrobial drugs like trimethoprim and sulfonamides.
Structural highlights
Three loop regions surround the HPPK active site. Upon binding of ATP, the loop region changes its conformation and enables the binding of HMDP.
