Ankyrin

From Proteopedia

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spinqualitylabelsall models Human ankyrin-1 D34 region complex with Cl- (green) and Br- (dark red) ions 1n11 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Function

Ankyrins (ANK) are proteins which mediate the attachment of membrane proteins to the membrane skeleton. ANKRD2 belongs to the conserved muscle ankyrin repeat protein (MARP) family.Also known as Arpp or stretch responsive muscle ANKRD2 gene contains 9 exons and spans about 12 kb. The 5-prime flanking region contains a TATA box and binding motifs for the muscle-specific transcription factors MYOD and for NF-kappa-B. Kemp et.al cloned mouse Ankrd2 and obtained a partial human ANKRD2 cDNA. Northern blot and PCR analyses detected expression of mouse Ankrd2 only in tissues containing striated muscle. In situ hybridization of mouse embryos showed that Ankrd2 expression was restricted to the myotome of somites at day 9.5. At later developmental stages, Ankrd2 expression was stronger in outer back muscles than intercostal muscles, and it was not expressed in heart. See also

• Group:MUZIC:ANKRD2
  
• Group:MUZIC:CARP
  
• Group:MUZIC:DARP.

Structural highlights

Ankyrin contains four domains: the N terminal which contains 24 ankyrin repeats, a spectrin-binding domain, a death domain which binds to proteins involved in apoptosis and a C terminal regulatory domain. The full-length 328-amino acid mouse protein contains an ATP/GTP-binding domain in its N-terminal half and an ankyrin repeat region in its C-terminal half. It also has a nuclear localization signal, 2 protein-destabilizing PEST sequences, and 2 phosphorylation sites. The ankyrin repeat is a protein-protein interaction motif. It is a 33 residue segment consisting of 2 α-helices connected by a loop.

3D Structures of Ankyrin

Updated on 02-November-2015