Function
Adenosine kinase (AdK) catalyzes the transfer of phosphate from ATP to adenosine to produce AMP. AMP-PCP is a non-hydrolyzable ATP analog.
Disease
AdK deficiency causes hypermethioninemia. Overexpression of AdK in the brain leads to decrease of adenosine and is believed as the main cause of epilepsy.
Structural highlights
AdK consists of a large α/β domain with 9 β strands and 8 α helices and a small capping α/β domain with 5 β strands and 2 α helices. The active site is formed along the edge of the β sheet in the large domain.
