Function
Arylamine N-acetyltransferase (NAT) catalyzes the transfer of an acetyl group from acetyl-CoA to an arylamine. Human NAT have 2 polymorphs with different substrate specificities. NAT1 acetylates p-aminisalycilates while NAT2 acetylates hydralazine.
Disease
Human NAT1 is overexpressed in some kinds of breast cancer.
Relevance
Acetylation is a major route of biotransformation for many arylamines and hydrazine drugs and known carcinogens like cigarette smoke. The levels of NAT in the body has important consequences with regard to an individual’s susceptibility to certain drug-induced toxicities and cancer.
Structural highlights
NAT acetylates using a catalytic Cys-His-Asp triad.
3D structures of arylamine N-acetyltransferase
Updated on 05-November-2015
