Casein kinase

Function

Casein kinase (CK) is a protein kinase which functions as regulator of signal transduction.

• CK1 is a serine/threonine kinase with several members: α, β1, γ1, γ2, γ3, δ and ε.
  
• CK2 functions in cell cycle control, DNA repair and circadian rhythm regulation.

Structural highlights

CK2 is a tetramer with a pair of 2 subunits – the α subunit is the catalytic one and the β subunit is the regulatory one. CK1 inhibitors bind in the ATP binding pocket.