This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


CD2-associated protein

From Proteopedia

Revision as of 07:55, 29 November 2015 by Michal Harel (Talk | contribs)
Jump to: navigation, search

Structure of human CD2AP SH3 domain 1 (green) complex with E3 ubiquitin ligase peptide (deeppink) (PDB entry 2j6o)

Drag the structure with the mouse to rotate

Contents


Function

CD2-associated protein (CD2AP) called also CMS, is a scaffolding protein which regulates actin cytoskeleton. CD2AP SH3 domain interacts with actin and a variety of membrane proteins. CD2AP contains in its N-terminal 3 SH3 domains followed by a proline-rich region.[1][2]

Disease

Haploinsufficiency of CD2AP is associated with susceptibility of glomerular disease

3D structures of CD2-associated protein

Updated on 29-November-2015

References

  1. ↑ Dikic I. CIN85/CMS family of adaptor molecules. FEBS Lett. 2002 Oct 2;529(1):110-5. PMID:12354621
  2. ↑ Moncalian G, Cardenes N, Deribe YL, Spinola-Amilibia M, Dikic I, Bravo J. Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain. J Biol Chem. 2006 Dec 15;281(50):38845-53. Epub 2006 Oct 3. PMID:17020880 doi:10.1074/jbc.M606411200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/CD2-associated_protein"
Personal tools