4pli

Structural highlights

Function

[MRG2_ARATH] Chromatin remodeling factor. Acts as a 'reader' protein by binding to H3K4me3 and H3K36me3 to control histone H4 acetylation. Increases the transcriptional levels of the flowering time genes FLC and FT (PubMed:25183522, PubMed:25211338). Binds the chromatin at the FT promoter upon interaction with CO (PubMed:25211338).^{[1] [2]}

References

1. ↑ Xu Y, Gan ES, Zhou J, Wee WY, Zhang X, Ito T. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res. 2014;42(17):10960-74. doi: 10.1093/nar/gku781. Epub 2014 Sep, 2. PMID:25183522 doi:http://dx.doi.org/10.1093/nar/gku781
2. ↑ Bu Z, Yu Y, Li Z, Liu Y, Jiang W, Huang Y, Dong AW. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. PLoS Genet. 2014 Sep 11;10(9):e1004617. doi: 10.1371/journal.pgen.1004617., eCollection 2014 Sep. PMID:25211338 doi:http://dx.doi.org/10.1371/journal.pgen.1004617