Beta-2 microglobulin

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Template:STRUCTURE 3mrb

Diagram of MHC I Complex
Diagram of MHC I Complex














Beta-2 microglobulin (B2M) is a component of MHC class I system. B2M associates with MHC class I α chain, CD1 and Qa. Loss of B2M function causes iron excess. For more details, see: Human beta two microglobulin.

Disease

Elevated B2M levels are found in patients of live cirhossis.

Relevance

B2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma.

3D Structures of β-2 microglobulin

Updated on 30-November-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, David Canner

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