A Disintegrin And Metalloproteinase

From Proteopedia

Revision as of 10:50, 30 November 2015 by Michal Harel (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 2ao7

Function

A Disintegrin And Metalloproteinase (ADAM) are peptidases which cleave off extracellular portions of transmembrane proteins. ADAM family members are numbered.

  • ADAM10 cleaves ephrin.
  • ADAM13 details are in Molecular Playground/ADAM13.
  • ADAM17 (TACE) processes the tumor necrosis factor-α.
  • ADAM33 is implicated in asthma.
  • ADAMTS is ADAM with thrombospondin motifs.
  • ADAMTS1 has anti-angionenic activity.
  • ADAMTS4 and ADAMTS5 are involved in the degradation of aggrecan.
  • ADAMTS13 cleaves von Willebrand factor involved in blood clotting.

Disease

ADAM inhibitors are used in anti-cancer therapy. ADAM33 is implicated in asthma. ADAMTS13 cleaves von Willebrand factor involved in blood clotting.


3D Structures of A Disintegrin And Metalloproteinase

Updated on 30-November-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/A_Disintegrin_And_Metalloproteinase"
Personal tools