Agrin
From Proteopedia
Contents |
Function
Agrin (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors.
Disease
Agr is overexpressed in brains of Alzheimer Disease patients. Agr is associated with myasthenic syndrome.
Structural highlights
Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor.
3D Structures of Agrin
Updated on 02-December-2015
3i70, 1pxu – cNtA – chicken
1pz7, 1pz8, 1pz9 – cAgr
1q56 – cAgr LMB G3+Ca – NMR
1jb3, 1jc7 – cAgr LMB
3pve – Agr LMB G2 - mouse
3v65, 3v64 – Agr LMB G3 + Low-density lipoprotein receptor-related protein 4 - rat
