Anti-silencing factor

Function

Anti-silencing factor (ASF) or histone chaperone assits in chromatin assembly and remodeling during replication, transcription activation and gene silencing. ASF cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with histone regulatory homolog A (HIRA) to promote replication-independent assembly.

Structural highlights

ASF has an 80 residue segment which binds RNA at the N-terminal and a C-terminal which is composed of 80% Ser and Arg.