Acylaminoacyl peptidase

From Proteopedia

spinqualitylabelsall models Acylaminoacyl peptidase dimer complex with acetyl and glycerol 2hu7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Acylaminoacyl peptidase or Acylamino-acid releasing enzyme (AARE, EC number 3.4.19.1) cleaves N-acetyl or N-formyl amino acid from the N-terminal of polypeptides.[1] Structural highlights AARE contains a (in olive) and an (in green). . The enzyme exists in an open state in which the oxyanion active site is accessible to the substrate and in a closed state where the active site is blocked.

3D Structures of Acylaminoacyl peptidase

Updated on 03-December-2015

3o4g, 3o4h, 3o4i, 3o4j, 2hu5, 2hu7, 2hu8, 1ve6 – ApAARE – Aeropyrum pernix
2qr5, 2qzp – ApAARE (mutant)
1ve7 – ApAARE+p-nitrophenyl phosphate
3fnb – AARE – Streptococcus mutans

References

1. ↑ Harmat V, Domokos K, Menyhard DK, Pallo A, Szeltner Z, Szamosi I, Beke-Somfai T, Naray-Szabo G, Polgar L. Structure and catalysis of acylaminoacyl peptidase: closed and open subunits of a dimer oligopeptidase. J Biol Chem. 2010 Nov 16. PMID:21084296 doi:10.1074/jbc.M110.169862