Sortase enzymes are trans-peptidases found in Gram-positive bacterial species. Their purpose is to covalently link proteins to the cell wall. By recognizing a specific sequence on target proteins, they “sort” which proteins to attach. Different sortases are separated into different classes based on their recognition sequence and specific function. Sortase A (SrtA) found in Staphylococcus aureus was the first sortase enzyme to be isolated in the lab in 1999 and has become the prototypical sortase [1]. Because surface proteins play such a big role in a pathogen’s virulence, sortases have become an important topic for study [2].
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Structural highlights
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
