Sandbox viralpackagingmotors
From Proteopedia
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Viral Packaging
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One of the most important stage in the life cycle of all viruses is the encapsidation (packaging) of the viral genome. Many virus package their genome into preformed capsids using packaging motors powered by the hydrolysis of ATP. The hexameric ATPase P4 of dsRNA bacteriophage phi 12, located at the vertices of the icosahedral capsid is such a packaging motor. [1] P4 protein is a 35-kDa ssRNA packaging ATPase Viruses like tailed dsDNA bacteriophages among others package their genome into empty capsids via a portal vertex complex. The RNA packaging motor is powered by the hydrolysis of ATP.
Function
The RNA packaging motor is a straightforward machinery that consists of a portal protein (P4) hexamer. It is the P4 protein that provides energy for RNA translocation.
Disease
The two methods of virion nucleic acid packaging known are (1) co-condensation of the nucleic acid with viral capsid proteins to form a virus particle ( employed by viruses such as HIV, TMV, AND M13 and (2) translocation of the nucleic acid into the a preformed procapsid shell ( found in eukaryotic viral families such as herpes and tailed dsDNA bacteriophages such T4, lambda and phi29, among others). [2]
Relevance
Structural highlights
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References
- ↑ Mancini EJ, Kainov DE, Grimes JM, Tuma R, Bamford DH, Stuart DI. Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation. Cell. 2004 Sep 17;118(6):743-55. PMID:15369673 doi:10.1016/j.cell.2004.09.007
- ↑ doi: https://dx.doi.org/10.1039/9781849732239-00203
