Sandbox T4SS

Bacterial type IV secretions systems move DNA and proteins out of a cell. Usually transfer of this DNA/proteins requires cell-to-cell contact, however one type of T4SS releases DNA from the extracellular milieu^[1].

[2] or to the article describing Jmol [3] to the rescue.

GENERAL STRUCTURE FEATURES OF TYPE 4 SECRETION SYSTEMS

With different functions comes many variations on the structure of T4SS, however the most well understood set of structures were studied through the Gram-negative bacteria A. tumefaciens. It is called the VirB/VirD4 system.

VirB is made up of 11 different VirB proteins systhesized from the virB operon. Most T4SS have homologes of these 12 proteins (11 from VirB and 1 from VirD)

VirB

Overview of T4SS structures^[4]

Function

Disease

Relevance

Structural highlights

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