Function
Dehalogenases catalyze the removal of halogen atom from substrates.
• Haloalkane dehalogenase converts haloalkanes to alcohol[1]
• Halohydrin dehalogenase converts halohydrins to epoxide
• L-2 haloacid dehalogenase converts L-2-haloacids to D-2-hydroxyacid
• S-2 haloacid dehalogenase converts S-2-haloacids to R-2-hydroxyacid
• 4-chlorobenzoyl CoA dehalogenase converts 4-chlorobenzoyl CoA to 4-hydroxybenzoyl CoA
• Fluoroacetate dehalogenase converts fluoroacetate to glycolate
• Iodotyrosine dehalogenase converts iodotyrosine to tyrosine
• cis- and trans-3-chloroacrylic acid dehalogenase converts 3-chloroacrylate to malonate semialdehyde
• 5-chloromuconolactone dehalogenase converts 5-chloromuconolactone to E-dienelactone.
• Tetrachloroethene reductive dehalogenase catalyzes the conversion of trichloroethene, Cl- and acceptor to tetrachloroethene and reduced acceptor.
Disease
Relevance
Haloalkane dehalogenase is tested for the biodegredation of toxic industrial by-products.
Structural highlights
