Function
Cytochrome c oxidase (CcO) is a transmembrane protein complex found in bacteria and mitochondria. CcO is the last enzyme in the electron transport chain. [1]
Disease
CcO deficiency is a genetic condition which affects muscle weakness, muscle tone upto severe brain dysfunction in severe cases.
Structural highlights
Mammalian CcO is composed of , , and cytochrome a and a3. The fully oxidized form of CcO active site shows the heme, Cu+2 ion and an O2 molecule.[2] Bacterial CcO is composed of 2 subunits.
