Diphtheria toxin repressor

Diphtheria toxin repressor (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. The DtxR regulates the expression of high affinity iron uptake system. ^[1]

Structural highlights

DtxR structure contains a DNA-binding domain (DBD) containing the helix-turn-helix motif at the N-terminal, an interface domain containing the metal-binding sites and a flexible C-terminal.