Diphtheria toxin repressor

Diphtheria toxin repressor (DtxR) is an iron-dependent repressor which is synthesized by the diphtheria bacterium when it is in iron-poor environment. The DtxR regulates the expression of high affinity iron uptake system. ^[1]

Structural highlights

DtxR structure contains an which contains DNA-binding domain (DBD) with a helix-turn-helix motif, dimerization and metal-binding residues. A C-terminal domain folds into SH3-like conformation. DtxR contains 2 metal binding sites.^[2]