Filamin

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Image:3hop.png
Crystal structure of Human Filamin A complex with phosphate, 3hop

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  • Filamin A (FLNA) has an actin-binding domain (ABD). It crosslinks actin filaments and participates in anchoring of membrane proteins.
  • Filamin B (FLNB) is a human cytoplasmic protein which functions similarly to FLNA and guides proper skeletal development.
  • Filamin C (FLNC) is functionally similar and contains 3 domains: the N-terminal ABD, the C-terminal dimerization domain (DD) and a membrane glycoprotein-binding domain.

For more details on filaminC see Group:MUZIC:FilaminC. The images at the left and at the right correspond to one representative filamin structure, i.e. the crystal structure of human filamin A (3hop), it forms a [1]. Two phosphate ions are rendered as space filling objects.

3D structures of filamin

Updated on 25-November-2014

References

  1. ↑ Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009 Dec 15;18(24):4791-800. Epub 2009 Sep 22. PMID:19773341 doi:10.1093/hmg/ddp442

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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