Estrogen-related receptor

From Proteopedia

proteopedia linkproteopedia link

spinqualitylabelsall models Human estrogen-related receptor γ ligand-binding domain (cyan, grey, green, yellow, pink, purple) complex with nuclear receptor corepressor 2 peptide (dark red, orange) and 4-hydroxytamoxifen (PDB code 2gpv) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Estrogen-related receptor (ERR) binds to estrogen response elements on DNA and modulates transcription in response to hormone. There are 3 classes of ERR : ERRα, ERRβ and ERRγ. Relevance ERR plays a role in energy homeostasis and cancer[1].

3D structures of estrogen-related receptor

Updated on 20-January-2016

References

1. ↑ Ariazi EA, Jordan VC. Estrogen-related receptors as emerging targets in cancer and metabolic disorders. Curr Top Med Chem. 2006;6(3):203-15. PMID:16515477