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Structure
The C-reactive protein is a homopentamer of non-covalently bound subunits. Each subunit is a 25 Da protein consisting of 224 residues bound together. The secondary structure is formed of four α-helices and three β-sheets (five-stranded, three-stranded and seven-stranded).[3] The predominant structure is β-sheet.[4] Residues Glu197 and Lys123 in CRP form an intermolecular ion pair.[5]
Calcium binding-site
PC interaction
PC stands for phosphocoline. It is a phospholipid in cell membranes and a plasma lipoproteins.[5]
Function
Biomedical interest
CRP level is 1000 times higher in a cytokine-mediated response due to tissue injury, infection and inflammation. Therefore the CRP rate in serum is common use to detect the activity of a disease.[5]
Structural highlights
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