BA42 belongs to the TPM protein family from Pfam. The TPM domain family is named after the three founding proteins TLP18.3, Psb32 and MOLO-1. TPM domains have a characteristic fold composed of α helices (3+3[2] or 2+3[3]) flanking four central β strands. The TPM fold has not been found in other protein domains to date. TPM was previously referred to as "DUF477" and "Repair_PSII".
In plants, the TPM domain-containing proteins TLP18.3 and Psb32 that have been implicated in the photosystem II (PSII) repair cycle. It may be involved in the regulation of synthesis/degradation of the D1 protein of the PSII core and in the assembly of PSII monomers into dimers in the grana stacks.[4]
In the model nematode C. elegans, the MOLO-1 protein is an auxiliary subunit that positively modulates the gating of levamisole-sensitive acetylcholine receptors.[5]
in Antarctic bacterium protein BA42 (PDB code 4oa3).[6]
Disease
PSAP is found in increased amounts in patients who have prostate cancer.
Relevance
PSAP was used as a prostate cancer marker before the develpement of prostate specific antigen (PSA) as one.
Structural Highlights
in E. coli acid phosphatase.[7]
