Glucose 6-phosphate dehydrogenase

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spinqualitylabelsall models Structure of human glucose 6-phosphate dehydrogenase complex with glucose 6-phosphate, glycolic acid and glycerol (PDB code 1qki). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Disease 3 Relevance 4 Structural highlights Function Glucose 6-phosphate dehydrogenase (G6PD) catalyzes the conversion of glucose 6-phosphate to 6-phospho-glucono-1,5-lactone. G6PD uses NAPD as cofactor[1]. See also G6PD (Hebrew). Disease G6PD deficiency predisposes toward hemolytic anemia[2]. Relevance Structural highlights

3D structures of glucose 6-phosphate dehydrogenase

Updated on 03-February-2016

References

1. ↑ Tian WN, Braunstein LD, Pang J, Stuhlmeier KM, Xi QC, Tian X, Stanton RC. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem. 1998 Apr 24;273(17):10609-17. PMID:9553122
2. ↑ Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008 Jan 5;371(9606):64-74. doi: 10.1016/S0140-6736(08)60073-2. PMID:18177777 doi:http://dx.doi.org/10.1016/S0140-6736(08)60073-2