Structural highlights
Function
[DPO4_SULSO] Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis.[HAMAP-Rule:MF_01113]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Studies on several recently discovered error-prone DNA polymerases reveal novel structures that may explain the low fidelity of this general class of enzymes, a number of which are involved in the replicative bypass (translesion synthesis) of base damage in DNA.
Error-prone DNA polymerases: novel structures and the benefits of infidelity.,Friedberg EC, Fischhaber PL, Kisker C Cell. 2001 Oct 5;107(1):9-12. PMID:11595180[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Friedberg EC, Fischhaber PL, Kisker C. Error-prone DNA polymerases: novel structures and the benefits of infidelity. Cell. 2001 Oct 5;107(1):9-12. PMID:11595180
