1jug
From Proteopedia
|
LYSOZYME FROM ECHIDNA MILK (TACHYGLOSSUS ACULEATUS)
Overview
A lysozyme isolated from the milk of a monotreme, the echidna, Tachyglossus aculeatus multiaculeatus, has been crystallized (space group, P2(1), with unit-cell dimensions a = 37.1, b = 42.0, c = 38.1 A, beta = 91, degrees and Z = 2) and the structure refined to an R value of 0.167 for, all measured data in the resolution range 7.0-1.9 A. It had previously, been inferred from sequence homology with alpha-lactalbumins that echidna, milk lysozyme (EML) would bind one calcium ion per molecule. This has been, confirmed in the present study in which the largest peak in a difference, Fourier synthesis is associated with a calcium ion. The calcium binding, site of EML is very similar to that observed in baboon and human, alpha-lactalbumins, and in a human lysozyme engineered to contain a, ... [(full description)]
About this Structure
1JUG is a [Single protein] structure of sequence from [Tachyglossus aculeatus] with CA as [ligand]. Active as [Lysozyme], with EC number [3.2.1.17]. Structure known Active Site: CAB. Full crystallographic information is available from [OCA].
Reference
Structure of the calcium-binding echidna milk lysozyme at 1.9 A resolution., Guss JM, Messer M, Costello M, Hardy K, Kumar V, Acta Crystallogr D Biol Crystallogr. 1997 Jul 1;53(Pt 4):355-63. PMID:15299900
Page seeded by OCA on Tue Oct 30 15:40:53 2007
